Electron transfer in human cytochrome P450 reductase.
نویسندگان
چکیده
Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 31 Pt 3 شماره
صفحات -
تاریخ انتشار 2003